Encapsulation of water-insoluble drugs in polymer capsules prepared using mesoporous silica templates for intracellular drug delivery

Y Wang; Y Yan; J Cui; L Hosta-Rigau; JK Heath; EC Nice; F Caruso

Journal article

Encapsulation of water-insoluble drugs in polymer capsules prepared using mesoporous silica templates for intracellular drug delivery

Y Wang, Y Yan, J Cui, L Hosta-Rigau, JK Heath, EC Nice, F Caruso

Advanced Materials | Published : 2010

DOI: 10.1002/adma.201001497

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Abstract

Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

University of Melbourne Researchers

Joan Heath Author

Frank Caruso Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

We thank Dr. A. N. Zelikin and S.-F. Chong for helpful discussions regarding the thiol-disulfide chemistry and for providing the PMA<INF>SH-</INF> PharmaMar S. A. (Spain) is gratefully acknowledged for providing the thiocoraline compound. This work was supported by the Australian Research Council under the Federation Fellowship and Discovery Project schemes (F. C.) and by the National Health and Medical Research Council (NHMRC) Project Grant 433613 (J. K. H., F. C., E. C. N.) and Program Grant 487922 (J. K. H., F. C.). J. C. acknowledges the China Scholarship Council for a joint-Education PhD Program Scholarship.